Whole genome sequencing informs SNP-based breeding strategies to safeguard genetic diversity in captive African lions

IntroductionAfrican lions (Panthera teal horse blanket leo) face severe population declines, making captive breeding programs essential for conservation.However, genetic data scarcity in such programs elevates inbreeding risks and threatens genetic diversity.MethodsUsing next-generation sequencing (NGS), we analyzed genome-wide genetic markers from

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MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Summary: Hematopoiesis is particularly sapatilha infantil prata glitter sensitive to DNA damage.Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy.It is not known why hematopoietic cells are highly vulnerable to DNA damage.Addressing this question is complicated by the paucity of mouse models of hematopoiet

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